Topical Drug Addiction: Adverse Effects of Fluorinated Corticosteroid Creams and Ointments

The adverse effects which the anti-inflammatory powers of topical fluorinated corticosteroids have on acne rosacea, “seborrhæic” complexions and tinea infection of the skin are illustrated by several cases. These steroids also cause local atrophy, purpura, telangiectasia and ulceration by interfering with skin collagen metabolism. Many patients are afraid to stop using the locally applied steroids because of the uncomfortable rebound inflammation which follows their withdrawal. Both the skin and the patient can therefore become readily “hooked” on these topical drugs.