Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location
Key result
Epicardial adipose tissue exhibited 2728 significantly up-regulated genes compared to subcutaneous fat, with distinct transcriptomic patterns depending on its anatomical location.
Population
41 patients paired for cardiovascular risk factors, CAD, and atrial fibrillation providing samples of…
Comparison
Pangenomic transcriptomic analysis of epicardial… vs Thoracic subcutaneous fat
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for epicardial fat-targeted therapies; leaves open links to clinical cardiovascular outcomes.
Study Design
Type
Observational (n=41)
Structured PICO
P
Population
41 patients paired for cardiovascular risk factors, coronary artery disease, and atrial fibrillation providing epicardial and subcutaneous fat samples.
E
Exposure
Pangenomic transcriptomic analysis of epicardial adipose tissue (EAT) from peri-atrial, peri-ventricular, and peri-coronary locations
C
Comparator
Thoracic subcutaneous fat
O
Outcome
Transcriptomic signature and differentially expressed genessurrogate
Human epicardial adipose tissue exhibits distinct transcriptomic signatures depending on its anatomical location, suggesting localized functional interactions with the myocardium and coronary arteries.
Cite This Study
Gaborit et al. (2015) conducted an observational in Cardiovascular risk factors, coronary artery disease, and atrial fibrillation (n=41). Epicardial adipose tissue (EAT) vs. Thoracic subcutaneous fat was evaluated on Transcriptomic signature (differentially expressed genes). Epicardial adipose tissue exhibited 2728 significantly up-regulated genes compared to subcutaneous fat, with distinct transcriptomic patterns depending on its anatomical location.