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January 1, 2016Clinical Medicine Insights Case ReportsOpen Access

Amiodarone-Induced Pulmonary Toxicity – A Frequently Missed Complication

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Key result

A 56-year-old male developed severe amiodarone-induced pulmonary toxicity post-CABG, which resolved after discontinuing amiodarone and initiating oral prednisone.

Population

56-year-old male with a past medical history of coronary artery disease and chronic obstructive pulmonary…

Design

Case_report

Authors

ASAlexander J. SweidanNSNavneet Kumar SinghNDNatasha Dang

Discussion

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Overview

Case report of APT underscores monitoring need in amiodarone patients; leaves open questions on incidence and risk stratification.

Study Design

Type

Case Report (n=1)

Structured PICO

P
Population
A 56-year-old male with CAD and COPD who developed amiodarone-induced pulmonary toxicity post-CABG after 3 months of amiodarone therapy.
E
Exposure
Amiodarone 400 mg orally twice daily (continued home dose, taken for the past 3 months).
O
Outcome
Amiodarone pulmonary toxicity (hypoxemia, bilateral infiltrates, dyspnea).safety

Amiodarone pulmonary toxicity should be considered in patients with extensive amiodarone use who present with new-onset dyspnea and radiographic infiltrates, particularly following major cardiothoracic surgery.

Limitations

  • A baseline pulmonary function test (PFT) did not exist prior
  • A DLCO was not done in this patient, therefore not every type of interstitial lung disease could be ruled out
  • Lack of baseline pulmonary function test (PFT)
  • DLCO was not performed, so not every type of interstitial lung disease could be definitively ruled out

Cite This Study

Sweidan et al. (2016) conducted a case report in Amiodarone-induced pulmonary toxicity (n=1). Amiodarone was evaluated on Amiodarone pulmonary toxicity. A 56-year-old male developed severe amiodarone-induced pulmonary toxicity post-CABG, which resolved after discontinuing amiodarone and initiating oral prednisone.

synapsesocial.com/papers/6a5d777eeea3ca2688880595https://doi.org/10.4137/ccrep.s39809
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1C42-40 Rhythm Control to Respiratory Collapse: A Case of Acute Amiodarone Pulmonary Toxicity2026
  2. 2Amiodarone-Associated Pulmonary Toxicity: A Clinical and Pathologic Study of Eleven Cases1987 · 100 citations
  3. 3Amiodarone-induced pulmonary toxicity with an excellent response to treatment: A case report2019 · 23 citations
  4. 4Severe amiodarone induced pulmonary toxicity.2012 · 37 citations
  5. 5Rapid onset of amiodarone induced pulmonary toxicity after lung lobe resection - A case report and review of recent literature2017 · 25 citations