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A chemically driven molecular information ratchet is described. The equilibrium macrocycle distribution in a 2rotaxane is driven away from its 50:50 population of thread binding sites to a 33:67 ratio by benzoylation under the influence of a chiral catalyst. The reaction corresponds to a dynamic kinetic resolution of rotaxane co-conformers that interconvert through shuttling.
Álvarez et al. (Fri,) studied this question.
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