Key result
Three large linkage studies comprising over 1000 sibling pairs found no significant evidence of linkage at the DISC1 locus on chromosome 1 for schizophrenia.
No support for DISC1 linkage in schizophrenia; challenges prior reports and leaves open polygenic or rare-variant models.
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Timothy J. Crow (2007) conducted a letter in Schizophrenia or schizoaffective disorder (n=1,144). DISC1 gene locus was evaluated on Genetic linkage (Lod score). Three large linkage studies comprising over 1000 sibling pairs found no significant evidence of linkage at the DISC1 locus on chromosome 1 for schizophrenia.
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