Key result
DISC1 protein aggregates disrupt intracellular transport in neurons via recruitment to the aggresome.
Why the study?
Protein aggregation has been suggested as a disease mechanism for DISC1, but its role in DISC1 function and intracellular transport is not fully understood.
DISC1 protein aggregation may serve as a disease mechanism in major psychiatric disorders by disrupting intracellular transport.
Hypothesis-generating for DISC1 aggregation in psychiatric disorders; should not yet change clinical practice.
Disrupted in Schizophrenia 1 (DISC1) is a key susceptibility gene for major psychiatric disorders. DISC1 plays a role in key neuronal processes such as neuronal proliferation, migration, integration and function via DISC1's roles at the centrosome and synapse, and in the regulation of intracellular signaling pathways. Recently, the idea of protein aggregation as a disease mechanism for DISC1 has been suggested. In our recent paper we explore these DISC1 protein aggregates in cell lines and neurons and find they are recruited to the aggresome and cause disruption of DISC1 function in intracellular transport.
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Atkin et al. (2012) studied Major psychiatric disorders. DISC1 protein aggregates was evaluated on Disruption of DISC1 function in intracellular transport. DISC1 protein aggregates are recruited to the aggresome and cause disruption of DISC1 function in intracellular transport in cell lines and neurons.
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