Key result
Exercise training in rats with pulmonary hypertension decreased right ventricular end-diastolic pressure and lipid peroxidation, inducing an efficient antioxidant adaptation.
Why the study?
The study was conducted to evaluate the effects of exercise training on oxidative stress in the gastrocnemius muscle of rats with pulmonary hypertension.
Does exercise training improve oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension?
Does exercise training improve oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension?
Exercise training induces an efficient antioxidant adaptation in skeletal muscle, preventing oxidative damage to lipids in a rat model of pulmonary arterial hypertension.
Exercise may induce skeletal muscle antioxidant adaptation in PAH rat models; hypothesis-generating and should not yet change practice.
The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50–60 min/session, at 60% of VO2 max. Right ventricular (RV) pressures were measured, heart and gastrocnemius were removed for morphometric/biochemical analysis. Lipid peroxidation (LPO), H2O2, GSH/GSSG, and activity/expression of antioxidant enzymes were evaluated. Increased RV hypertrophy, systolic and end-diastolic pressures (RVEDP) were observed in SM animals, and the RVEDP was decreased in TM vs. SM. H2O2, SOD-1, and LPO were higher in the SM group than in SC. In TM, H2O2 was further increased when compared to SM, with a rise in antioxidant defences and a decrease in LPO. GSH/GSSG was higher only in the TC group. Exercise induced an efficient antioxidant adaptation, preventing oxidative damage to lipids.
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Becker et al. (2020) studied Pulmonary arterial hypertension. Exercise training vs. Sedentary was evaluated on Oxidative stress markers (LPO, H2O2, GSH/GSSG) and right ventricular pressures. Exercise training in rats with pulmonary hypertension decreased right ventricular end-diastolic pressure and lipid peroxidation, inducing an efficient antioxidant adaptation.
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