Key result
A single bout of exercise normalized elevated right ventricular systolic pressure and augmented pulmonary endothelial nitric oxide synthase activation in a rat model of pulmonary arterial hypertension.
Why the study?
Does acute exercise reduce pulmonary artery pressure and right ventricular wall stress in a rat model of pulmonary arterial hypertension?
Does acute exercise reduce pulmonary artery pressure and right ventricular wall stress in a rat model of pulmonary arterial hypertension?
Acute exercise at moderately high intensity reduces pulmonary artery pressure and increases vasorelaxor signaling without causing right ventricular inflammation or apoptosis in a rat model of PAH.
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May support acute exercise effects in experimental PAH; leaves open translation to patients and long-term outcomes.
Brown et al. (2015) studied Pulmonary arterial hypertension (n=20). Acute exercise vs. Healthy control animals was evaluated on Right ventricular systolic pressure, systemic pressure, and right ventricular inflammation or apoptosis. A single bout of exercise normalized elevated right ventricular systolic pressure and augmented pulmonary endothelial nitric oxide synthase activation in a rat model of pulmonary arterial hypertension.
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