Key result
Increasing bone marrow angioblasts trafficking to the infarct zone resulted in dose-dependent neovascularization, improved cardiac function, and endogenous cardiomyocyte regeneration.
Why the study?
Does increasing the trafficking of bone marrow angioblasts to the infarct zone improve cardiac function and induce cardiomyocyte regeneration in ischemic myocardium?
Population
Ischemic myocardium model (specific animal or in vivo model not detailed in abstract)
Design
Preclinical
Authors
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Hypothesis-generating for angioblast homing post-MI; leaves open clinical translation in humans.
Does increasing the trafficking of bone marrow angioblasts to the infarct zone improve cardiac function and induce cardiomyocyte regeneration in ischemic myocardium?
Increasing myocardial homing of bone marrow angioblasts can induce endogenous cardiomyocytes to enter the cell cycle and improve functional cardiac recovery after ischemic injury.
Schuster et al. (2004) studied Ischemic myocardium. Bone marrow angioblasts was evaluated on Neovascularization and cardiomyocyte regeneration. Increasing bone marrow angioblasts trafficking to the infarct zone resulted in dose-dependent neovascularization, improved cardiac function, and endogenous cardiomyocyte regeneration.
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