Key result
Higher cardio-ankle vascular index (CAVI) was an independent predictor of primary idiopathic complete atrioventricular block in elderly patients (OR 2.575; 95% CI 1.390-4.770; P=.003).
Why the study?
The study aimed to investigate the relationship between primary idiopathic complete atrioventricular block and arterial stiffness assessed by the cardio-ankle vascular index.
Is arterial stiffness, as measured by the cardio-ankle vascular index (CAVI), associated with primary idiopathic complete atrioventricular block in an elderly population?
Case-Control (n=81)
Is arterial stiffness, as measured by the cardio-ankle vascular index (CAVI), associated with primary idiopathic complete atrioventricular block in an elderly population?
Odds Ratio: 2.575 (95% CI 1.39–4.77)
Absolute Event Rate: 9.63% vs 8.57%
p-value: p=.003
Increased arterial stiffness, measured by CAVI, is independently associated with primary idiopathic complete atrioventricular block in elderly patients.
Elevated CAVI may flag iCAVB risk in elderly patients; leaves open causality and need for prospective validation before clinical use.
The most common cause of complete atrioventricular block (CAVB) is age-related fibrotic degeneration and is referred to as primary idiopathic complete atrioventricular block (iCAVB). This study aims to investigate the relationship between iCAVB and arterial stiffness using the cardio-ankle vascular index (CAVI). In this study, of 205 CAVB patients, 41 patients with iCAVB implanted with a dual-chamber permanent pacemaker and 40 age- and gender-matched controls were studied. Arterial stiffness was assessed by a VaSera VS-1000 CAVI instrument. The CAVI values of patients with iCAVB were significantly higher compared with the controls (9.63 ± 1.42 vs 8.57 ± 1.12, P < .001). Idiopathic complete atrioventricular block frequency was higher among patients with abnormal CAVI values than those with borderline and normal CAVI ( P = .04). In multivariate analysis, only CAVI was an independent predictor of iCAVB after adjusting for other relevant factors (odds ratio, 2.575; 95% CI [1.390-4.770]; P = .003). The present study demonstrated that CAVI, as a marker of arterial stiffness, was increased among elderly patients with iCAVB. Thus, we provide a possible additional mechanism linking easily measured CAVI with iCAVB.
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Turan et al. (2021) conducted a case-control in Primary idiopathic complete atrioventricular block (iCAVB) (n=81). Cardio-ankle vascular index (CAVI) vs. Age- and gender-matched controls was evaluated on Primary idiopathic complete atrioventricular block (iCAVB) (OR 2.575, 95% CI 1.390-4.770, p=.003). Higher cardio-ankle vascular index (CAVI) was an independent predictor of primary idiopathic complete atrioventricular block in elderly patients (OR 2.575; 95% CI 1.390-4.770; P=.003).
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