What question did this study set out to answer?

This research aims to develop a population pharmacokinetic model for colistin methanesulfonate and colistin in critically ill patients.

Population Pharmacokinetics of Colistin Methanesulfonate and Formed Colistin in Critically Ill Patients from a Multicenter Study Provide Dosing Suggestions for Various Categories of Patients

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Randomized trial investigates dosing regimens of colistin in critically ill patients, suggesting dosing tailored for renal function.

This research aims to develop a population pharmacokinetic model for colistin methanesulfonate and colistin in critically ill patients.
Studied 105 patients, including those on hemodialysis and continuous renal replacement therapy.
Collected 8 blood samples per patient for pharmacokinetic analysis during therapy.
Utilized a linear pharmacokinetic model to analyze data with creatinine clearance and body weight as covariates.
Developed dosing suggestions for critically ill patients, especially for those on renal replacement therapy.
Demonstrated significant variance in creatinine clearance among patients not on renal replacement, ranging from 3 to 169 ml/min/1.73 m².
Recommended colistin be part of a combination therapy for patients with adequate renal function and high MICs.

Garonzik et al. (2011) studied this question.

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