Key result
Combined aPTT, fibrinogen, and creatinine strongly predict 28-day mortality in septic shock from enteric perforation.
Why the study?
Septic shock is a leading cause of ICU mortality, prompting evaluation of clinically available factors associated with 28-day mortality.
Does the combination of APTT, fibrinogen, and creatinine predict 28-day mortality in patients with septic shock caused by acute enteric perforation?
Observational (n=138)
No
Does the combination of APTT, fibrinogen, and creatinine predict 28-day mortality in patients with septic shock caused by acute enteric perforation?
The combination of APTT, fibrinogen, and creatinine shows high prognostic value for predicting 28-day mortality in patients with septic shock from enteric perforation.
Answers are grounded in this paper and cite their sources.
May identify prognostic factors in perioperative septic shock; hypothesis-generating and requires prospective validation.
BACKGROUND: Septic shock is one of the leading causes of mortality in intensive care units. This retrospective study was carried out to evaluate the association of clinical available factors with 28-day mortality. PATIENTS AND METHOD: In this observational study, patients with perioperative septic shocks secondary to intra-abdominal infection caused by enteric perforation were included. A total of 328 sepsis patients were admitted to the surgical intensive care units from January 2012 to December 2016. A total of 138 patients met the enrolment criteria and were included in the study. The data of demographic, clinical and laboratory were all recorded. RESULT: All these 138 patients received abdominal surgery prior to surgical intensive care units caused by acute enteric perforation. These patients were all met the diagnostic criteria of septic shock according to Sepsis-3. Statistical analysis showed that lactic acid, blood platelet, fibrinogen, creatinine and activated partial thromboplastin time were found to be associated with 28-day mortality. A combination of serum activated partial thromboplastin time combined with fibrinogen and creatinine could predict in-hospital 28-day mortality. The area under the curve of serum activated partial thromboplastin time combined with fibrinogen and creatinine is 0.875 (0.806-0.944). CONCLUSION: In conclusion, this pilot study demonstrated that these factors can predict the prognosis of septic shock caused by enteric perforation. In order to reduce the mortality, surgeons and intensive care units physician may consider these data in perioperative period.
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Fu et al. (2023) conducted an observational in Septic shock caused by acute enteric perforation (n=138). Serum activated partial thromboplastin time combined with fibrinogen and creatinine was evaluated on 28-day mortality (AUC 0.875, 95% CI 0.806-0.944). A combination of serum activated partial thromboplastin time, fibrinogen, and creatinine strongly predicted 28-day mortality in patients with septic shock caused by acute enteric perforation (AUC 0.875).
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