Key result
The rs10033464 SNP at chromosome 4q25 was significantly associated with an increased risk of atrial fibrillation in a Hispanic/Latino cohort (adj. OR 2.27, 95% CI 1.31-3.94; P = 3.3 x 10^-3).
Why the study?
Do atrial fibrillation risk SNPs identified in European populations increase susceptibility to atrial fibrillation in Hispanics/Latinos?
Case-Control (n=713)
No
Do atrial fibrillation risk SNPs identified in European populations increase susceptibility to atrial fibrillation in Hispanics/Latinos?
The rs10033464 SNP at chromosome 4q25 is associated with increased susceptibility to atrial fibrillation in Hispanic/Latino patients, extending genetic risk findings from European populations.
rs10033464 near PITX2 was associated with incident AF in Hispanics; hypothesis-generating and requires validation before clinical use.
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Chalazan et al. (2018) conducted a case-control in Atrial Fibrillation (n=713). rs10033464 SNP at chromosome 4q25 vs. Reference allele was evaluated on Development of atrial fibrillation (adj. OR 2.27, 95% CI 1.31-3.94, p=3.3 x 10^-3). The rs10033464 SNP at chromosome 4q25 was significantly associated with an increased risk of atrial fibrillation in a Hispanic/Latino cohort (adj. OR 2.27, 95% CI 1.31-3.94; P = 3.3 x 10^-3).
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