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May 15, 2017European Heart JournalOpen Access

Genetic heterogeneity of atrial fibrillation susceptibility loci across racial or ethnic groups

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Population

672 Korean patients with early-onset AF who had undergone radiofrequency catheter ablation and 3700 controls…

Comparison

Genome-wide association study (GWAS) vs Patients without AF

Design

Editorial

Authors

HHHenry D. HuangUniversity of ChicagoDDDawood DarbarBroad Institute

Discussion

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Implication

This editorial highlights the genetic heterogeneity of atrial fibrillation susceptibility across racial and ethnic groups, emphasizing the discovery of novel loci in a Korean cohort.

Structured PICO

P
Population
672 Korean patients with early-onset AF (age <60 years) who had undergone radiofrequency catheter ablation and 3700 controls without AF (discovery cohort); replication cohort of 200 AF patients and 1812 controls.
I
Intervention
Genome-wide association study (GWAS)
C
Comparator
Patients without AF
O
Outcome
Identification of genetic susceptibility loci for atrial fibrillationsurrogate

This editorial highlights the genetic heterogeneity of atrial fibrillation susceptibility across racial and ethnic groups, emphasizing the discovery of novel loci in a Korean cohort.

Limitations

  • Inadequate power to replicate all loci
  • Differing minor allele frequencies across racial/ethnic groups
  • Highly selected group of patients (early-onset AF undergoing ablation)

Cite This Study

Huang et al. (2017) studied this question.

synapsesocial.com/papers/6a796c26dd2e05b79c32074chttps://doi.org/10.1093/eurheartj/ehx289

Topics

Atrial fibrillationPersistent AF managementAnticoagulation in AF
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Also Consider

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  1. 1Korean atrial fibrillation network genome-wide association study for early-onset atrial fibrillation identifies novel susceptibility loci2017 · 77 citations
  2. 2Genetic Investigation Into the Differential Risk of Atrial Fibrillation Among Black and White Individuals2016 · 51 citations
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  5. 5Parental Atrial Fibrillation as a Risk Factor for Atrial Fibrillation in Offspring2004 · 602 citations