Key result
Two novel genetic loci at PPFIA4 and HAND2 linked to early-onset AF in Korean patients.
Why the study?
Some AF susceptibility loci identified by GWAS in European databases showed ethnic differences in Asian populations, prompting exploration of novel variants for early-onset AF in Korean patients undergoing catheter ablation.
What are the genetic susceptibility loci for early-onset atrial fibrillation in Korean patients?
Population
672 early-onset AF cases and 3700 controls, with 200 cases and 1812 controls in replication
Comparison
Early-onset AF cases vs controls
Design
Genome-wide association study with independent replication
Authors
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Novel Korean AF loci in early-onset cases require replication; leaves open ancestry-specific risk models and functional studies.
Case-Control (n=6,384)
Yes
What are the genetic susceptibility loci for early-onset atrial fibrillation in Korean patients?
p-value: p=6.84 × 10-10 and 1.49 × 10-11
Identified two novel genetic loci (1q32.1/PPFIA4 and 4q34.1/HAND2) associated with early-onset atrial fibrillation in a Korean population, highlighting ethnic differences in genetic susceptibility.
Kim et al. (2017) conducted a case-control in Early-onset atrial fibrillation (n=6,384). Genetic variants at 1q32.1/PPFIA4 and 4q34.1/HAND2 vs. Controls without early-onset AF was evaluated on Association with early-onset atrial fibrillation (p=6.84 × 10-10 and 1.49 × 10-11). Two novel genetic loci on chromosomes 1q32.1/PPFIA4 (P = 6.84 × 10-10) and 4q34.1/HAND2 (P = 1.49 × 10-11) were significantly associated with early-onset atrial fibrillation in Korean patients.
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