The Impact of Obesity on the Association between Vitamin D Deficiency and Cardiovascular Disease
Key result
Obesity may act as a critical confounder in the association between vitamin D deficiency and cardiovascular disease, suggesting supplementation might only benefit obese adults at increased CVD risk.
Why the study?
Despite strong associations between vitamin D deficiency and cardiovascular outcomes, supplementation trials in the general population have failed to reduce cardiovascular events and mortality.
Does vitamin D supplementation reduce cardiovascular events and mortality in the general population and obese adults?
Structured PICO
Does vitamin D supplementation reduce cardiovascular events and mortality in the general population and obese adults?
P
Population
General population and obese adults with increased risk for cardiovascular disease
E
Exposure
Vitamin D supplementation
O
Outcome
Cardiovascular events and mortalityhard clinical
Obesity may confound the relationship between vitamin D deficiency and cardiovascular disease, suggesting that targeted supplementation might only benefit obese adults at increased CVD risk rather than the general population.
Authors
Discussion
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Implication
Should not change vitamin D supplementation practice; leaves open need for obesity-stratified RCTs on CVD outcomes.
Cite This Study
Paschou et al. (2019) conducted a review in Cardiovascular disease and vitamin D deficiency. Vitamin D deficiency and obesity was evaluated. Obesity may act as a critical confounder in the association between vitamin D deficiency and cardiovascular disease, suggesting supplementation might only benefit obese adults at increased CVD risk.