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This work aims to explore how film thickness affects protein adsorption from blood serum and plasma on poly(sulfobetaine) surfaces.

August 2, 2008Langmuir

Film Thickness Dependence of Protein Adsorption from Blood Serum and Plasma onto Poly(sulfobetaine)-Grafted Surfaces

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Randomized trial investigates protein adsorption on poly(sulfobetaine) surfaces, suggesting optimal film thickness for minimizing fouling.

This work aims to explore how film thickness affects protein adsorption from blood serum and plasma on poly(sulfobetaine) surfaces.
Investigated protein adsorption from single protein solutions and complex media (100% blood serum and plasma) on poly(sulfobetaine methacrylate)-grafted surfaces.
Utilized atom transfer radical polymerization to create varying film thicknesses of polySBMA brushes.
Analyzed surface resistance to protein adsorption across different thicknesses.
Optimal film thickness for minimal protein adsorption identified at 62 nm with enhanced nonfouling characteristics in blood serum and plasma.
All tested surfaces demonstrated high resistance to specific proteins like fibrinogen and lysozyme.
Findings suggest a new standard for evaluating biomaterials intended for blood-contacting applications.

Yang et al. (2008) studied this question.

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Randomized trial investigates protein adsorption on poly(sulfobetaine) surfaces, suggesting optimal film thickness for minimizing fouling.