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Experimental evaluation reveals that nitrogen dioxide is essential for nitrosation in pharmaceuticals, suggesting countermeasure adjustments.
High Resolution Image Download MS PowerPoint Slide We have previously clearly identified atmospheric nitrogen oxides (NOx) as a key factor in nitrosamine contamination in pharmaceuticals. To implement more appropriate countermeasures, the nitrosation potential of nitrogen monoxide (NO) and nitrogen dioxide (NO 2 )─the primary components of NOx─was evaluated using short-term and long-term gas flow model experiments. The results revealed that NO 2 is required for the nitrosation reaction to occur.
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NOMURA et al. (2026) studied this question.
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