Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 20, 2026Future Microbiology

Molecular analysis of clinical Acinetobacter baumannii isolates based on colistin resistance, biofilm formation, clonal relationships, and pmr A gene expression

View Full Paper
Ask AI
Bookmark
Share

Authors

MSMohammad Reza ShakibaieKerman University of Medical SciencesMGMohammad Reza Kandehkar GhahramanIranshahr UniversityFMFaeze MahdiunKerman University of Medical Sciences

Discussion

Loading...

Member takes

Overview

Randomized trial investigates molecular characteristics of colistin-resistant A. baumannii isolates, highlighting antibiotic stewardship needs.

Key Points

  • This research aims to analyze multidrug-resistant Acinetobacter baumannii isolates focusing on colistin resistance and associated molecular characteristics.
  • Collected 20 MDRAB isolates from patients in an intensive care unit.
  • Conducted antimicrobial susceptibility testing using broth microdilution and assessed clonal relatedness through Repetitive-element PCR.
  • Analyzed pmrA gene expression using quantitative RT-PCR and detected relevant resistance genes.
  • Isolates presented high MICs against carbapenems with strong biofilm formation (bap, csuE, pgaA, ompA genes detected).
  • 94% of isolates had class 1 integrons and 65% carried the blaCTX-M gene.
  • Colistin-resistant isolates displayed a distinct Rep-PCR profile and harbored pmrA and blaCTX-M-15 genes.

Cite This Study

Shakibaie et al. (2026) studied this question.

synapsesocial.com/papers/6a5dba718bd453d3397ab98chttps://doi.org/10.1080/17460913.2026.2704354
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibiotic Resistance and Biofilm Gene Distribution in Colistin‐Resistant <i>Acinetobacter baumannii</i>2026
  2. 2Molecular Characterization and Clonal Analysis of Carbapenem‐Resistant <i>Acinetobacter baumannii</i> : Insights Into Biofilm‐Related Gene Coexistence in Clinical Isolates2026 · 1 citations
  3. 3Molecular Characterization of Colistin Resistance Acinetobacter baumannii Isolates and Identification of Mutations in pmrA and lpxA Genes from a Tertiary Care Hospital in South India2026
  4. 4Virulence Traits, Colistin Resistance and Carbapenemase Production in Multidrug-Resistant Acinetobacter baumannii: A Phenotypic Study from South India2025
  5. 5Genetic alterations in the pmrAB two-component system and lipid A biosynthesis genes of polymyxin-resistant Acinetobacter baumannii isolates2024