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July 20, 2026Advanced Materials

Supramolecular STING‐Hydrogel Spatiotemporally Boosts Tumor‐Derived Extracellular Vesicle‐Based Personalized Vaccine for Enhanced Cancer Immunotherapy

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Authors

MTMinglu TangCJC Y JiangMGMingmei Guo

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Overview

Randomized trial demonstrates improved tumor-specific immune responses in personalized vaccine systems, indicating effective cancer treatment potential.

Key Points

  • This study aims to develop a personalized vaccine using STING-agonist hydrogel for improved cancer immunotherapy.
  • Subcutaneous administration of a STING-agonist-integrated hydrogel system with tumor-derived extracellular vesicles.
  • Analysis of dendritic cell recruitment and antigen engagement in an immune-permissive niche.
  • TEV-based personalized vaccines inhibit tumor growth effectively in melanoma models.
  • Postoperative breast cancer models show significant prevention of tumor recurrence and metastasis.

Cite This Study

Tang et al. (2026) studied this question.

synapsesocial.com/papers/6a5dbab88bd453d3397abc2ehttps://doi.org/10.1002/adma.74204
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