Recent Progress in Acyl Fluoride Synthesis

Acyl fluorides have garnered considerable interest in synthetic organic chemistry owing to their distinctive balance of stability and reactivity. Recent efforts toward their preparation have focused on the development of novel reaction modalities and milder, safer, and more efficient fluorinating reagents. This review systematically surveys the strategies for acyl fluoride synthesis reported over the past five years. 1 Introduction 2 Synthesis of acyl fluorides via halogen exchange 3 Synthesis of acyl fluorides via deoxyfluorination 4 Synthesis of acyl fluorides via Fluorocarbonylation 5 Conclusion and outlook