Extraintestinal manifestations have a negative impact on Quality of Life of patients with Inflammatory Bowel Disease

Background: Inflammatory Bowel Diseases (IBD) can produce extraintestinal manifestations (EIMs) in up to 50% of patients with IBD and may have worse quality of life than the general population. In general, IBD patients with activity have worse quality of life than those who are in remission. No previous studies have explored whether EIMs can affect the quality of life in patients with IBD. The aim of this study is to evaluate if the presence of EIM causes a worse Quality of life in patients with IBD. Methods: A case-control study that included 243 patients diagnosed with IBD (132 without EIM and 111 with EIM). The IBDQ-32 questionnaire was administered to all patients in order to measure the quality of life. The cutoff value to consider altered quality of life was less than 170 points. Statistical analysis was performed using SPSS version 25. Results: Patients with IBD with EIMs had significantly worse quality of life than those without EIMs (P=0.001; OR = 2.29, 95% CI: 1.3-3.8). In the subgroup analysis by dimensions of the IBDQ-32, we found that all of them like social function (P<0.0001); systemic symptoms (P<0.0001); intestinal symptoms (P<0.0001); and emotional (P<0.0001) were affected in all patients with EIMs. Conclusions: Patients with IBD and EIMs had worse quality of life compared than those without EIMs regardless of IBD activity.