Key result
LPS-binding protein (LBP) is physically associated with lipoproteins in plasma and acts as a necessary cofactor for the neutralization of LPS by high-density lipoproteins.
Population
In vitro model using normal human plasma, reconstituted HDL particles (R-HDL), and human neutrophils
Comparison
Addition of recombinant LPS binding protein to… vs Reconstituted HDL particles (R-HDL) alone
Design
Preclinical
Authors
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May protect against endotoxic shock in models; leaves open which HDL components mediate LPS neutralization for clinical translation.
LPS-binding protein is a constituent of apoA-I containing lipoproteins in plasma and acts as a necessary cofactor for the neutralization of bacterial LPS by HDL.
Wurfel et al. (1994) studied Gram-negative septic shock. Recombinant LPS binding protein (LBP) with reconstituted HDL vs. Reconstituted HDL alone was evaluated on Functional neutralization of LPS measured by CD14-dependent activation of leukocyte integrins on human neutrophils. LPS-binding protein (LBP) is physically associated with lipoproteins in plasma and acts as a necessary cofactor for the neutralization of LPS by high-density lipoproteins.
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