Key result
Inhibition of SDH by malonate promoted adult cardiomyocyte proliferation, revascularization, and heart regeneration within 4 weeks after myocardial infarction injury in mice.
Why the study?
Whether succinate and SDH regulate cardiomyocyte cell cycle activity and the cardiac metabolic state remains unclear.
Does succinate dehydrogenase inhibition by malonate promote cardiomyocyte proliferation and heart regeneration in mice after myocardial infarction?
Population
Neonatal, juvenile, and adult mice after myocardial infarction injury
Comparison
Succinate injection or SDH inhibition with malonate vs controls
Design
Preclinical animal study
Follow-up
4 weeks after injury
Authors
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Malonate should not change post-MI practice; hypothesis-generating for SDH inhibition in adult cardiac regeneration.
Does succinate dehydrogenase inhibition by malonate promote cardiomyocyte proliferation and heart regeneration in mice after myocardial infarction?
Inhibition of succinate dehydrogenase by malonate promotes adult cardiomyocyte proliferation and heart regeneration after myocardial infarction in mice, highlighting a potential metabolic reprogramming strategy for heart failure.
Bae et al. (2021) studied Myocardial infarction. Malonate was evaluated on Cardiomyocyte proliferation, revascularization, and heart regeneration. Inhibition of SDH by malonate promoted adult cardiomyocyte proliferation, revascularization, and heart regeneration within 4 weeks after myocardial infarction injury in mice.
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