Key result
Transgenic mice expressing constitutively active HIF-1α in epidermis displayed a 66% increase in dermal capillaries and a 13-fold elevation of VEGF expression without inducing edema or leakage.
Population
Transgenic mice expressing constitutively active hypoxia-inducible factor-1alpha (HIF-1alpha) in epidermis
Comparison
Overexpression of constitutively active HIF-1alpha vs Transgenic mice overexpressing VEGF cDNA in skin
Design
Preclinical
Authors
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HIF-1α activation may enable safer therapeutic angiogenesis; leaves open translation from this murine model to human ischemia.
HIF-1alpha overexpression induces functional hypervascularity without the adverse effects of vascular leakage or inflammation seen with direct VEGF overexpression, highlighting its potential for treating tissue ischemia.
Elson et al. (2001) studied this question. Constitutively active HIF-1α overexpression in epidermis was evaluated on Dermal capillaries and VEGF expression. Transgenic mice expressing constitutively active HIF-1α in epidermis displayed a 66% increase in dermal capillaries and a 13-fold elevation of VEGF expression without inducing edema or leakage.
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