Key result
Apixaban resolves idiopathic pulmonary vein thrombosis and symptoms in a reported case.
Why the study?
Pulmonary vein thrombosis is a potentially fatal, rare clinical finding with an unknown incidence rate that is documented predominantly in case reports.
Does apixaban resolve symptoms in a patient with idiopathic pulmonary vein thrombosis?
Case Report (n=1)
No
Does apixaban resolve symptoms in a patient with idiopathic pulmonary vein thrombosis?
This case report provides the first published evidence of successful treatment of idiopathic pulmonary vein thrombosis with a direct oral anticoagulant (apixaban).
May support apixaban in rare idiopathic pulmonary vein thrombosis; leaves open need for prospective validation before practice change.
Pulmonary vein thrombosis (PVT) is a rare clinical finding that is potentially fatal and with an unknown incidence rate as known cases exist predominantly in case reports. We present the case of a 58-year-old female who reported sudden onset of chest pain, shortness of breath, and dyspnoea on exertion. A computed tomography (CT) pulmonary angiogram was negative for evidence of pulmonary embolism; however, it did demonstrate the evidence of thrombosis of the right lower lobe segmental pulmonary vein. She had no identifiable aetiologies for her PVT; therefore, she was diagnosed with idiopathic PVT and was treated successfully with apixaban. This case represents the 14th incidence of idiopathic PVT in the current body of medical literature and the first case of successful treatment with apixaban.
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Ngo et al. (2021) conducted a case report in Idiopathic pulmonary vein thrombosis (n=1). Apixaban was evaluated on Symptom resolution. Apixaban successfully treated idiopathic pulmonary vein thrombosis, resulting in complete clinical resolution of symptoms in a 53-year-old female.
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