Key result
RNA-dependent RNA polymerase activity was found in the mitochondrial fraction of porcine cells infected with transmissible gastroenteritis virus, but not in uninfected cells or purified virus.
Authors
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Mitochondrial RdRp activity in TGEV-infected cells is hypothesis-generating; leaves open its role in coronavirus replication pending in vivo studies.
Dennis et al. (1982) studied Coronavirus infection (transmissible gastroenteritis virus of swine). Transmissible gastroenteritis virus of swine infection vs. Uninfected control cells was evaluated on RNA-dependent RNA polymerase activity. RNA-dependent RNA polymerase activity was found in the mitochondrial fraction of porcine cells infected with transmissible gastroenteritis virus, but not in uninfected cells or purified virus.
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