Key result
Prior tuberculosis treatment is linked to ~4 incident diabetes cases per 1000 person-years.
Why the study?
To estimate the incidence of diabetes, acute myocardial infarction, and stroke, and determine associated factors among patients previously treated for tuberculosis disease.
What is the incidence of diabetes, AMI, and stroke among patients previously treated for tuberculosis?
Cohort (n=157,444)
What is the incidence of diabetes, AMI, and stroke among patients previously treated for tuberculosis?
Answers are grounded in this paper and cite their sources.
Patients previously treated for tuberculosis have a notable incidence of diabetes, AMI, and stroke, which are predicted by pre-existing chronic non-communicable disease risk factors.
OBJECTIVES: To estimate the incidence of diabetes, acute myocardial infarction (AMI), and stroke; and to determine factors associated with diabetes, AMI, and stroke incidence among patients previously treated for tuberculosis (TB) disease. METHODS: A retrospective cohort study was conducted among non-pediatric TB patients registered in the Taiwan National Health Insurance Research Database (NHIRD) from 2002-2013. Diabetes, AMI, and stroke incidence were defined by International Classification of Diseases (ICD)-9 codes, drug prescriptions, and records of patient's clinic visits. Cox proportional hazard models were used to estimate the hazard rate ratio (HR) of incident diabetes, AMI, and stroke. RESULTS: From 2002-2013, there were 157,444 patients treated for TB registered in NHIRD. Among 129,453 patients with no prior history of diabetes, the age-adjusted incidence rate (IR) of diabetes was 3.85 (95%CI 3.70-4.01) per 1000 person-years. Among 143,646 patients with no prior history of AMI, the age-adjusted IR of AMI as 3.26 (95%CI 3.13-3.40). Among 118,774 patients with no prior history of stroke, the age-adjusted IR of stroke was 16.08 (95%CI 15.76-16.32). CONCLUSIONS: Chronic non-communicable disease risk factors like dyslipidemia, hypertension, and chronic kidney disease diagnosed before time of TB diagnosis were predictive of diabetes, AMI, and stroke incidence.
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Salindri et al. (2019) conducted a cohort in Prior tuberculosis disease (n=157,444). Prior tuberculosis infection and treatment vs. No unexposed control group was evaluated on Incidence of diabetes (95% CI 3.70-4.01). Among adult patients formerly treated for tuberculosis, the age-adjusted incidence rates of diabetes, acute myocardial infarction, and stroke were 3.85, 3.26, and 16.08 per 1000 person-years, respectively.
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