Key result
Latent tuberculosis infection linked to ~90% greater AMI risk.
Why the study?
Tuberculosis has been associated with increased risk of cardiovascular disease including acute myocardial infarction, but the association of latent tuberculosis infection with AMI was unclear.
Is latent tuberculosis infection associated with an increased risk of acute myocardial infarction?
Case-Control (n=215)
Yes
Is latent tuberculosis infection associated with an increased risk of acute myocardial infarction?
Odds Ratio: 1.9 (95% CI 1.05–3.45)
Absolute Event Rate: 64% vs 49%
p-value: p=0.03
Latent tuberculosis infection is independently associated with nearly double the odds of acute myocardial infarction, suggesting it may be an unrecognized cardiovascular risk factor.
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Latent TB may represent a novel MI risk factor; this case-control association is hypothesis-generating and requires prospective validation.
Huamán et al. (2017) conducted a case-control in Acute myocardial infarction (n=215). Latent tuberculosis infection (LTBI) vs. No latent tuberculosis infection was evaluated on Acute myocardial infarction (adjusted OR 1.90, 95% CI 1.05-3.45, p=0.03). Latent tuberculosis infection was independently associated with acute myocardial infarction (adjusted OR 1.90; 95% CI 1.05-3.45).
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