Key result
Depletion of natural killer cells during experimental autoimmune myocarditis significantly increased disease severity, fibrosis, and caused a 10-fold increase in cardiac-infiltrating eosinophils.
Why the study?
Does NK cell depletion increase myocarditis severity and eosinophil infiltration in mice with experimental autoimmune myocarditis?
Population
BALB/c mice and eosinophil-deficient ΔdoubleGATA1 mice immunized with myocarditogenic peptide to induce…
Comparison
Depletion of NK cells using anti-asialo GM1… vs Mice with intact NK cells (no depletion)
Design
Preclinical
Authors
Loading...
NK cells may limit eosinophil-driven myocarditis severity in mice; hypothesis-generating for human autoimmune disease.
Does NK cell depletion increase myocarditis severity and eosinophil infiltration in mice with experimental autoimmune myocarditis?
Natural killer cells protect against autoimmune myocarditis and subsequent fibrosis by limiting eosinophil infiltration.
Ong et al. (2015) studied Experimental autoimmune myocarditis. Depletion of NK cells (anti-asialo GM1 antibody) vs. Control (intact NK cells) was evaluated on Myocarditis severity, fibrosis, and cardiac-infiltrating eosinophils. Depletion of natural killer cells during experimental autoimmune myocarditis significantly increased disease severity, fibrosis, and caused a 10-fold increase in cardiac-infiltrating eosinophils.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: