Key result
Ticlopidine and clopidogrel (100 µm) induced >80% concentration-dependent, endothelium-independent vasorelaxation in precontracted rat arterial tissues.
Why the study?
Do ticlopidine and clopidogrel cause direct vasorelaxation and affect smooth muscle cell proliferation independent of hepatic bioactivation in rat arterial tissues?
Population
Rat caudal arterial rings and aortic smooth muscle cells in culture
Comparison
Ticlopidine and clopidogrel (0.01 µm-100 µm) vs Acetylcholine and various pharmacological…
Design
Preclinical
Authors
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Thienopyridines may exert direct vasorelaxant effects; this Level 5 finding leaves open clinical relevance and requires confirmation.
Do ticlopidine and clopidogrel cause direct vasorelaxation and affect smooth muscle cell proliferation independent of hepatic bioactivation in rat arterial tissues?
Ticlopidine and clopidogrel directly induce endothelium-independent vasorelaxation and inhibit smooth muscle cell proliferation without requiring hepatic biotransformation.
Froldi et al. (2011) studied this question. Ticlopidine and clopidogrel vs. Acetylcholine was evaluated on Vasorelaxation in arterial tissues precontracted with phenylephrine, 5-hydroxytryptamine and KCl. Ticlopidine and clopidogrel (100 µm) induced >80% concentration-dependent, endothelium-independent vasorelaxation in precontracted rat arterial tissues.
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