The Relationship between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria

Three sequential phases of mitochondrial calcium accumulation can be distinguished: matrix dehydrogenase regulation, buffering of extramitochondrial free calcium, and finally activation of the permeability transition. Relationships between these phases, free and total matrix calcium concentration, and phosphate concentration are investigated in rat liver and brain mitochondria. Slow, continuous calcium infusion is employed of and brain permeability matrix calcium are of infusion the permeability transition. the in the of free matrix calcium concentration, in the total matrix calcium of of phosphate the free matrix calcium and the matrix the permeability is matrix free calcium of calcium infusion in permeability activation in between and matrix free calcium concentration of total matrix of is the matrix free calcium concentration, and the matrix is the in the matrix free calcium Three sequential phases of mitochondrial calcium accumulation can be distinguished: matrix dehydrogenase regulation, buffering of extramitochondrial free calcium, and finally activation of the permeability transition. Relationships between these phases, free and total matrix calcium concentration, and phosphate concentration are investigated in rat liver and brain mitochondria. Slow, continuous calcium infusion is employed of and brain permeability matrix calcium are of infusion the permeability transition. the in the of free matrix calcium concentration, in the total matrix calcium of of phosphate the free matrix calcium and the matrix the permeability is matrix free calcium of calcium infusion in permeability activation in between and matrix free calcium concentration of total matrix of is the matrix free calcium concentration, and the matrix is the in the matrix free calcium of and and is in is and is and the permeability transition. is of the matrix and of calcium phosphate is the matrix of phosphate is matrix can total concentration can be of total matrix total matrix matrix free extramitochondrial free rat liver rat brain total matrix matrix free extramitochondrial free rat liver rat brain the of the in liver and brain are the free concentration of matrix free is the of calcium phosphate and is of the of liver brain can is the of the and is in the of 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