Key result
Ventrolateral periaqueductal gray stimulation powerfully depressed noxious cold-evoked withdrawal reflexes to 0.1% of baseline and selectively inhibited noxious cold-evoked activity in spinal neurons.
Absolute Event Rate: 0.1% vs 100%
p-value: p=<0.01
Descending control from the periaqueductal gray selectively modulates the spinal transmission of noxious versus innocuous cold information, providing insights into central processing of cold somatosensation.
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PAG descending control modulates spinal cold responses; leaves open translation to clinical cold allodynia mechanisms.
Leith et al. (2010) studied Normal physiology (pain processing) (n=38). Ventrolateral periaqueductal gray (VL-PAG) stimulation vs. Baseline (pre-stimulation) was evaluated on Noxious cold-evoked withdrawal reflex magnitude and dorsal horn neuronal activity (p=<0.01). Ventrolateral periaqueductal gray stimulation powerfully depressed noxious cold-evoked withdrawal reflexes to 0.1% of baseline and selectively inhibited noxious cold-evoked activity in spinal neurons.
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