Key result
68Ga-FAPI PET/CT successfully identified a primary lung adenocarcinoma in a patient with rectal cancer, establishing a diagnosis of double primary malignancies.
Why the study?
Does 68Ga-FAPI PET/CT improve detection of second primary malignancies compared to 18F-FDG PET/CT in a patient with rectal cancer?
Case Report (n=1)
Does 68Ga-FAPI PET/CT improve detection of second primary malignancies compared to 18F-FDG PET/CT in a patient with rectal cancer?
68Ga-FAPI PET/CT can improve therapeutic strategy by detecting second primary malignancies that may be missed or indeterminate on standard 18F-FDG PET/CT.
May aid detection of occult second primaries; leaves open superiority over 18F-FDG in prospective studies.
A 71-year-old man with pathologically confirmed rectal cancer underwent F-FDG PET/CT before radical operation, which showed multiple nodules with low uptake in bilateral pleura and 1 solitary pulmonary nodule with slight uptake in left lung. The subpleural nodule was diagnosed as benign lesion through the biopsy. Ga-labeled fibroblast-activation-protein inhibitor PET/CT was performed for further evaluation, which showed low uptake in bilateral subpleural nodules but focally increased uptake in the nodule of left lung. This nodule was found to be a primary lung adenocarcinoma by the CT-guided biopsy. A diagnosis of rectum and lung double primary malignancies was finally made.
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Chen et al. (2020) conducted a case report in Rectal cancer (n=1). 68Ga-FAPI PET/CT vs. 18F-FDG PET/CT was evaluated on Detection of a second primary malignancy. 68Ga-FAPI PET/CT successfully identified a primary lung adenocarcinoma in a patient with rectal cancer, establishing a diagnosis of double primary malignancies.
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