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August 22, 2012PLoS ONEOpen Access

Optimization of Cardiovascular Stent against Restenosis: Factorial Design-Based Statistical Analysis of Polymer Coating Conditions

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Key result

Stents coated with a polycaprolactone (PCL) matrix containing S-Nitrosoglutathione (GSNO) displayed sustained drug release profiles and the least platelet adhesion compared to PLGA and PEG coatings.

Population

Stents coated with various polymers as carriers for S-Nitrosoglutathione (GSNO)

Comparison

Polycaprolactone matrix coating containing GSNO vs Poly and polyethylene glycol matrix coatings

Design

Preclinical

Authors

GAGayathri AcharyaShobhit UniversityCLChi‐Ho LeeQueen Mary HospitalYLYugyung LeeUniversity of Missouri–Kansas City

Discussion

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Implication

Merits in vivo testing before any clinical consideration; leaves open whether PCL-GSNO coatings reduce restenosis.

Structured PICO

P
Population
Stents coated with various polymers as carriers for S-Nitrosoglutathione (GSNO)
I
Intervention
Polycaprolactone (PCL) matrix coating containing GSNO
C
Comparator
Poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) matrix coatings
O
Outcome
GSNO release rate, weight loss rate, and platelet adhesion ratesurrogate

A polycaprolactone (PCL) matrix containing the nitric oxide prodrug GSNO provides sustained drug release and reduced platelet adhesion, representing a promising stent coating to prevent restenosis.

Limitations

  • In vitro study only, requiring in vivo validation.
  • Irregular and porous surface morphology due to fast solvent evaporation requires further optimization.

Cite This Study

Acharya et al. (2012) studied Restenosis. S-Nitrosoglutathione (GSNO) loaded polycaprolactone (PCL) polymer coating vs. PLGA and PEG coatings, or bare metal stent was evaluated on GSNO release rate and weight loss rate. Stents coated with a polycaprolactone (PCL) matrix containing S-Nitrosoglutathione (GSNO) displayed sustained drug release profiles and the least platelet adhesion compared to PLGA and PEG coatings.

synapsesocial.com/papers/6a5dfca979db1288b9f673c7https://doi.org/10.1371/journal.pone.0043100
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vitro evaluation of the safe margin, antithrombotic and antiproliferative actions for the treatment of restenosis: Nitric oxide donor and polymers2011 · 13 citations
  2. 2Inhibition of thrombosis by a novel platelet selective S-nitrosothiol compound without hemodynamic side effects2004 · 28 citations
  3. 3l -Arginine and S -Nitrosoglutathione Reduce Embolization in Humans2001 · 81 citations