Key result
Tamoxifen treatment in women with breast cancer significantly increased the risk of ischemic stroke compared to controls (OR 1.82; 95% CI 1.41 to 2.36), with an absolute risk increase of 0.32%.
Why the study?
Does tamoxifen increase the risk of ischemic stroke in women with breast cancer?
Population
Women with breast cancer (data pooled from 9 randomized controlled trials)
Comparison
Tamoxifen vs Controls
Design
Meta-analysis
Follow-up
mean 4.9 years
Authors
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Meta-Analysis
Does tamoxifen increase the risk of ischemic stroke in women with breast cancer?
Odds Ratio: 1.82 (95% CI 1.41–2.36)
Absolute Event Rate: 0.71% vs 0.39%
Tamoxifen treatment for breast cancer significantly increases the relative risk of ischemic stroke, although the absolute risk remains small.
Bushnell et al. (2004) conducted a meta-analysis in breast cancer. Tamoxifen vs. controls was evaluated on ischemic stroke (OR 1.82, 95% CI 1.41 to 2.36). Tamoxifen treatment in women with breast cancer significantly increased the risk of ischemic stroke compared to controls (OR 1.82; 95% CI 1.41 to 2.36), with an absolute risk increase of 0.32%.
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