Key result
Timely recognition and targeted management of right ventricular failure, focusing on RV coronary perfusion, pulmonary vascular resistance, and volemia, can prevent irreversible cardiovascular collapse.
Why the study?
Right ventricular dysfunction and failure are common, often overlooked causes of perioperative deterioration that fail to respond to typical therapeutic measures, risking cardiovascular collapse.
Answers are grounded in this paper and cite their sources.
Early recognition and targeted management of right ventricular failure, focusing on perfusion, vascular resistance, and volume status, are essential to prevent perioperative mortality.
Right ventricular (RV) dysfunction and failure are common and often overlooked causes of perioperative deterioration and adverse outcomes. Due to its unique pathophysiologic underpinnings, RV failure often does not respond to typical therapeutic measures such as volume resuscitation and often worsens when therapy is escalated and mechanical ventilation is begun, with a danger of irreversible cardiovascular collapse and death. The single most important factor in improving outcomes in the context of RV failure is anticipating and recognizing it. Once established, a vicious circle of systemic hypotension, and RV ischemia and dilation is set in motion, rapidly spiraling down into a state of shock culminating in multi-organ failure and ultimately death. Therapy of RV failure must focus on rapidly reestablishing RV coronary perfusion, lowering pulmonary vascular resistance and optimizing volemia. In parallel, underlying reversible causes should be sought and if possible treated. In all stages of diagnostics and therapy, echocardiography plays a central role. In severe cases of RV dysfunction there remains a role for the use of the pulmonary artery catheter. When these mostly simple measures are undertaken in a timely fashion, the spiral of death of RV failure can often be broken or even prevented altogether.
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Wanner et al. (2020) conducted a review in Right ventricular dysfunction and failure. Timely recognition and targeted management of right ventricular failure, focusing on RV coronary perfusion, pulmonary vascular resistance, and volemia, can prevent irreversible cardiovascular collapse.
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