Key result
Inhaled milrinone reduces pulmonary vascular resistance without causing systemic hypotension in high-risk cardiac surgery.
RCT (n=21)
Double-blind
computerized random numbers
No
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Supports selective pulmonary vasodilation without hypotension in high-risk cardiac surgery; extends randomized evidence for right heart protection.
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jeanClaude Tardif a (2014) conducted an RCT in Preoperative pulmonary hypertension in high-risk cardiac surgery (n=21). Inhaled milrinone vs. Placebo (0.9% normal saline) was evaluated on Change in systemic mean arterial pressure (MAP). In high-risk cardiac surgery patients, inhaled milrinone did not cause systemic hypotension but reduced pulmonary vascular resistance and prevented right-sided cavity enlargement.
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