Key result
Older age (>40 years) and Hispanic ethnicity are independent poor prognostic factors for overall survival in Ewing sarcoma, with 5-year OS of 37.6% for >40 years vs 61% for <18 years (p=0.01).
Why the study?
Do ethnicity and age affect overall survival in patients with Ewing sarcoma?
Cohort (n=127)
Do ethnicity and age affect overall survival in patients with Ewing sarcoma?
Absolute Event Rate: 37.6% vs 61%
p-value: p=0.01
Older age and Hispanic ethnicity are associated with poorer overall survival in patients with Ewing sarcoma.
Should not yet alter risk stratification in Ewing sarcoma; hypothesis-generating for ethnicity- and age-specific outcomes in prospective studies.
This institutional retrospective review studied Ewing sarcomas from 1987-2011. Among 135 patients, 127 (19 Hispanic and 108 white/non-Hispanic) were analyzed (excluding small sample sized groups) finding 15% Hispanic, 85% non-Hispanic, 27% <18 years, 21% >40 years and 1-272 months follow-up (median 41). Age was significantly associated with overall survival (OS) (p = 0.01), whereby <18 years had a higher probability of 5-year survival (OS 61%) than >40 years (OS 37.6%). Ethnicity was marginally statistically significant (OS, p = 0.065); whereby median survival was clinically significant (white non-Hispanic 63 months and Hispanic 23 months). Hispanic ethnicity and older age are independent poor prognostic factors.
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Koohbanani et al. (2012) conducted a cohort in Ewing sarcoma (n=127). Older age (>40 years) and Hispanic ethnicity vs. Younger age (<18 years) and white non-Hispanic ethnicity was evaluated on 5-year overall survival (p=0.01). Older age (>40 years) and Hispanic ethnicity are independent poor prognostic factors for overall survival in Ewing sarcoma, with 5-year OS of 37.6% for >40 years vs 61% for <18 years (p=0.01).
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