The Prevalence of Advanced Interatrial Block and Its Relationship to Left Atrial Function in Patients with Transthyretin Cardiac Amyloidosis
Key result
Advanced interatrial block is common in ATTR-CA and is associated with reduced left atrial contractile function (OR 5.2; 95% CI 1.4-19.9).
Why the study?
Atrial amyloid deposition could reduce interatrial conduction, but the prevalence of advanced interatrial block and its relationship to left atrial function in ATTR-CA were unknown.
Population
75 patients (49 with ATTR-CA and 26 with HF and left ventricular hypertrophy but no CA)
Comparison
ATTR-CA vs HF with left ventricular hypertrophy but no CA
Design
Observational comparative study
Authors
Discussion
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Implication
Supports link to reduced atrial function in ATTR-CA; hypothesis-generating, requires prospective validation before clinical use.
Study Design
Type
Observational (n=75)
Structured PICO
P
Population
75 patients, comprising 49 with transthyretin cardiac amyloidosis and 26 with heart failure and left ventricular hypertrophy but no cardiac amyloidosis.
C
Comparator
Patients with heart failure and left ventricular hypertrophy but no cardiac amyloidosis (n=26).
O
Outcome
Prevalence of advanced interatrial block (aIAB) and its relationship to left atrial function (assessed via comprehensive echocardiography including left atrial strain and strain rate).surrogate
Main Result
Odds Ratio: 5.2 (95% CI 1.4–19.9)
Advanced interatrial block is common in patients with ATTR-CA and is independently associated with reduced left atrial contractile function.
Cite This Study
Lindow et al. (2021) conducted an observational in Transthyretin Cardiac Amyloidosis (ATTR-CA) (n=75). Transthyretin cardiac amyloidosis (ATTR-CA) vs. Heart failure with left ventricular hypertrophy but no cardiac amyloidosis was evaluated on Prevalence of advanced interatrial block (aIAB) and its relationship to left atrial function (OR 5.2, 95% CI 1.4-19.9). Advanced interatrial block is common in ATTR-CA and is associated with reduced left atrial contractile function (OR 5.2; 95% CI 1.4-19.9).