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Cross-kingdom polymicrobial wound infections present significant clinical challenges, including persistent pathogen colonization, delayed healing, and an elevated risk of complications. Despite the broad-spectrum antimicrobial activity and immunomodulatory properties of copper ions (Cu 2+ ), their therapeutic efficacy in infectious wound management is often suboptimal due to the lack of precise control of ion release kinetics. Here, we developed a dissolvable microneedle dressing loaded with our novel copper complex containing an Azo-Schiff base (Cu-Azo@DMN). This system demonstrates oxidative stress-mediated antimicrobial activity and enables pH-responsive Cu 2+ release in the acidic polymicrobial infection microenvironment. Furthermore, Cu-Azo@DMN also exhibits enhanced antimicrobial efficacy through photo-responsive Cu 2+ release. Following pathogen clearance, the system autonomously tunes down Cu 2+ release to resolve inflammation and promote angiogenesis, thereby facilitating tissue regeneration. Collectively, our findings feature Cu-Azo@DMN as a smart wound dressing that enables dual-responsive Cu 2+ release, offering a streamlined management of cross-kingdom polymicrobial infections and immunomodulation wound healing.
Ghosh et al. (Thu,) studied this question.