Key result
The pooled all-cause readmission rates for COPD within 30 and 90 days were 18% and 31%, respectively, with alcohol use, prior hospitalizations, and comorbidities identified as risk factors.
Why the study?
Information on all-cause readmissions in patients following hospitalization for COPD is limited, despite high readmission rates, increased mortality risk, and heavy economic burden.
Meta-Analysis
Patients hospitalized for COPD face high all-cause readmission rates of 18% at 30 days and 31% at 90 days, driven by comorbidities like heart failure and prior hospitalizations.
Answers are grounded in this paper and cite their sources.
High 30- and 90-day COPD readmission rates warrant targeted risk mitigation at discharge; confirms alcohol use, prior hospitalizations, and comorbidities as consistent predictors.
BACKGROUND: The readmission rate following hospitalization for chronic obstructive pulmonary disease (COPD) is surprisingly high, and frequent readmissions represent a higher risk of mortality and a heavy economic burden. However, information on all-cause readmissions in patients with COPD is limited. OBJECTIVE: This study aimed to systematically summarize all-cause COPD readmission rates within 30 and 90 days after discharge and their underlying risk factors. METHODS: Eight electronic databases were searched to identify relevant observational studies about COPD readmission from inception to 1 August 2022. Newcastle-Ottawa Scale was used for methodological quality assessment. We adopt a random effects model or a fixed effects model to estimate pooled all-cause COPD readmission rates and potential risk factors. RESULTS: A total of 28 studies were included, of which 27 and 8 studies summarized 30- and 90-day all-cause readmissions, respectively. The pooled all-cause COPD readmission rates within 30 and 90 days were 18% and 31%, respectively. The World Health Organization region was initially considered to be the source of heterogeneity. We identified alcohol use, discharge destination, two or more hospitalizations in the previous year, and comorbidities such as heart failure, diabetes, chronic kidney disease, anemia, cancer, or tumor as potential risk factors for all-cause readmission, whereas female and obesity were protective factors. CONCLUSIONS: Patients with COPD had a high all-cause readmission rate, and we also identified some potential risk factors. Therefore, it is urgent to strengthen early follow-up and targeted interventions, and adjust or avoid risk factors after discharge, so as to reduce the major health economic burden caused by frequent readmissions. TRIAL REGISTRATION: This systematic review and meta-analysis protocol was prospectively registered with PROSPERO (no. CRD42022369894).
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Ruan et al. (2023) conducted a meta-analysis in Chronic obstructive pulmonary disease (COPD). Risk factors (alcohol use, prior hospitalizations, comorbidities) was evaluated on 30-day all-cause readmission. The pooled all-cause readmission rates for COPD within 30 and 90 days were 18% and 31%, respectively, with alcohol use, prior hospitalizations, and comorbidities identified as risk factors.
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