Key result
Integrating advanced imaging with computer simulations comprehensively assesses atherosclerotic plaque vulnerability.
Why the study?
Assessing atherosclerosis severity and plaque vulnerability is crucial for preventing and treating CVD, and integrating imaging techniques with computer simulations yields insights into plaque inflammation, morphology, and intravascular stress.
Advanced imaging techniques combined with computer simulations offer a comprehensive approach to evaluating atherosclerotic plaque vulnerability and severity.
Links plaque vulnerability to CVD events; leaves open prospective validation of imaging biomarkers for risk stratification.
Atherosclerosis is an important cause of cerebrovascular and cardiovascular disease (CVD). Lipid infiltration, inflammation, and altered vascular stress are the critical mechanisms that cause atherosclerotic plaque formation. The hallmarks of the progression of atherosclerosis include plaque ulceration, rupture, neovascularization, and intraplaque hemorrhage, all of which are closely associated with the occurrence of CVD. Assessing the severity of atherosclerosis and plaque vulnerability is crucial for the prevention and treatment of CVD. Integrating imaging techniques for evaluating the characteristics of atherosclerotic plaques with computer simulations yields insights into plaque inflammation levels, spatial morphology, and intravascular stress distribution, resulting in a more realistic and accurate estimation of plaque state. Here, we review the characteristics and advancing techniques used to analyze intracranial and extracranial atherosclerotic plaques to provide a comprehensive understanding of atheroma.
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He et al. (2023) conducted a review in Atherosclerosis. Advanced imaging techniques (US, CT, MRI, PET, OCT, NIRS) was evaluated. Integrating advanced imaging techniques with computer simulations provides a comprehensive evaluation of atherosclerotic plaque characteristics, inflammation, and vulnerability.
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