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Demonstrates the efficiency of asymmetric syn-aldol reactions in producing valuable enantiomerically pure compounds from oxazinane-thiones, suggesting new synthetic pathways.
High Resolution Image Download MS PowerPoint Slide A direct and asymmetric syn -aldol reaction of N -acyl-1,3-oxazinane-2-thiones with dialkyl acetals from aromatic acetals in the presence of 2–5 mol % [DTBM-SEGPHOS]NiCl 2, TMSOTf, and lutidine has been developed. It has been established that the oxazinanethione heterocycle, used for the first time as a scaffold in asymmetric carbon–carbon bond-forming reactions, can be smoothly removed to give access to a variety of enantiomerically pure compounds with high synthetic value.
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Mellado‐Hidalgo et al. (2023) studied this question.
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