Key result
New GII.4 Sydney P16 norovirus accounts for ~60% of genotyped pediatric cases in Shanghai.
Observational (n=2,419)
No
Highlights the emergence of a new GII.4 Sydney[P16] norovirus variant causing increased gastroenteritis cases in children in China, emphasizing the need for ongoing surveillance.
Newly evolved GII.4 Sydney[P16] norovirus with multiple residue mutations, already circulating in parts of China, became predominant and caused an abrupt increase in diagnosed norovirus cases among children with gastroenteritis in Shanghai during 2021-2022. Findings highlight the need for continuous long-term monitoring for GII.4 Sydney[P16] and emergent GII.4 norovirus variants.
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Ao et al. (2023) conducted an observational in Norovirus-associated acute gastroenteritis (n=2,419). GII.4 Sydney[P16] norovirus vs. Other norovirus genotypes (e.g., GII.4 Sydney[P31]) was evaluated on Proportion of norovirus cases attributed to GII.4 Sydney[P16] in 2021. A newly evolved GII.4 Sydney[P16] norovirus sublineage emerged in 2020 and became the predominant genotype, accounting for 60% of genotyped norovirus cases among children with gastroenteritis in Shanghai in 2021.
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