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The crystallographic study of four acetophenone derivatives (1–4) is reported in the context of crystal engineering with a detailed analysis of Hirshfeld surfaces and fingerprint plots facilitating a comparison of intermolecular interactions in building different supramolecular self-assemblies. The X-ray study reveals that molecules of 1–4 are linked by cooperative weak C–H⋯O, C–H⋯π and π⋯π stacking interactions which are responsible for the formation and strengthening of molecular assembly. The substituting benzyl units are used as a potential scaffold for designing supramolecular self-assemblyvia C–H⋯π forces. Investigation of Hirshfeld surface analysis reveals a much more detailed scrutiny in comparison to these weak forces experienced by each compound. A comparison of Hirshfeld surfaces in the title derivatives with similar substituted and unsubstituted structures retrieved from the Cambridge Structural Database (CSD) has been presented.
Seth et al. (Sat,) studied this question.