Baseline serum vitamin A and vitamin C levels and their association with disease severity in COVID-19 patients.
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Key Points
This study investigates how serum levels of Vitamin A and C relate to the severity of COVID-19.
Fifty-three PCR(+) COVID-19 patients admitted to a dedicated ward were enrolled.
Blood samples were collected for serum Vitamin A and C measurements upon admission.
A control group of 26 healthy volunteers was included for comparison of serum levels.
COVID-19 patients had significantly lower serum Vitamin A (494±96 ng/ml vs. 698±93 ng/ml, p<0.001) and Vitamin C (2961 ng/ml vs. 3953 ng/ml, p=0.007) than controls.
Vitamin A was negatively correlated with length of hospitalization (r=-0.293; p=0.009) and CT severity score (r=-0.289; p=0.010).
Vitamin C showed even stronger negative correlations with length of hospitalization (r=-0.478; p<0.001) and CT severity score (r=-0.734; p<0.001).
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Implication
Randomized trial investigates vitamin A and C levels and COVID-19 severity in patients, suggesting dietary importance.