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AMP phosphorylase and its DPBB domains using multiscale simulations, energetic profiling, and rational redesign. Comparative structural-dynamics analyses across homologs uncover adaptation-linked paradigms integrating sequence divergence, rugged thermodynamics, and fold plasticity, highlighting evolutionary strategies driving thermostability and functional robustness under extreme physicochemical conditions.
Bhagat et al. (Wed,) studied this question.