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THE beta cells of the islands of Langerhans have a dominant role in the regulation of normal carbohydrate metabolism. These cells serve as depots of insulin reserve stored within their cytoplasm in the form of beta granules, and in the normal subject, insulin is released immediately after elevation of the level of blood glucose. In the diabetic subject it is probable that the beta cells play an important and dominant part in the etiology or pathogenesis of this disease. The possible mechanisms of their action in diabetes mellitus may be the result of one or more of the following: diminished . . .
Paul E. Lacy (Thu,) studied this question.