Key result
Providing TTR results to AF patients on warfarin increased discussions about switching to a NOAC compared to controls (19.1% vs 10.6%, P=0.03), but did not increase actual switching.
Why the study?
Does the provision of TTR results increase discussions about switching to NOACs in atrial fibrillation patients on warfarin?
Population
481 atrial fibrillation patients prescribed warfarin, mean CHA2DS2-VASc score 3.2, mean HASBLED score 1.7…
Comparison
Provision of time in therapeutic range results… vs No provision of TTR results (controls)
Design
RCT, randomised
Authors
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TTR feedback supports initiating anticoagulation discussions in AF; extends evidence on decision-support tools while leaving switching rates unchanged.
RCT (n=481)
Randomized
No
Does the provision of TTR results increase discussions about switching to NOACs in atrial fibrillation patients on warfarin?
Absolute Event Rate: 19.1% vs 10.6%
p-value: p=0.03
Providing TTR results to AF patients on warfarin increases clinical discussions about switching to NOACs, particularly in those with poor control, but does not significantly increase actual switching rates.
Huang et al. (2018) conducted an RCT in Atrial fibrillation (n=481). Provision of time in therapeutic range (TTR) results vs. No provision of TTR results was evaluated on A documented discussion between doctors and patients about switching warfarin to a non-vitamin K oral anticoagulant (NOAC) (p=0.03). Providing TTR results to AF patients on warfarin increased discussions about switching to a NOAC compared to controls (19.1% vs 10.6%, P=0.03), but did not increase actual switching.
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